The PBTC encourages the submission of concepts for consideration by the PBTC Scientific Committee.

Who May Submit
PBTC member investigator(s) may submit a concept for review.
Non-member investigator(s) may also submit a concept for PBTC review. If the concept is approved for development into a protocol, the expectations for the non-PBTC investigator(s) and affiliated institutions will be outlined at that time.
Investigators are encouraged to present their ideas to the PBTC New Agents Committee for verbal feedback before submitting their concept as a Letter of Intent (LOI). The New Agents Committee meets once per month.

Submission Format
Please use this LOI Form (MS Word).

Concept Development Support
Statistical design support is available for concepts submitted to the PBTC.

Where to Submit
Email the Operations, Biostatistics, and Management Core (OBDMC) Executive Director, Dr. Arzu Onar-Thomas.

Timing of Submission
Concepts may be submitted to the PBTC at any time.

PBTC Scientific Committee Review Process
The OBDMC coordinates the review process. Concepts are reviewed for scientific rationale, novelty/innovation, study design, feasibility, and patient and family considerations. Written feedback will be provided to the submitting investigator(s) during the process, and will conclude with a concept disposition letter, including the median final score by the PBTC Steering Committee and outcome.
If the concept is approved, the OBDMC will provide guidance for the next steps; if the concept is disapproved, it will not be developed further. If investigators are interested in submitting a related idea, the concept would need to be distinct, and the review process would start again.

Questions
Reach out to PBTC Project Manager, Ari Kennedy.